Fig. 1: Roles of FXR in the physiology and pathophysiology of the kidney. | Experimental & Molecular Medicine

Fig. 1: Roles of FXR in the physiology and pathophysiology of the kidney.

From: The role of the farnesoid X receptor in kidney health and disease: a potential therapeutic target in kidney diseases

Fig. 1

Schematic of the roles of FXR in kidney physiology and diseases. Activated FXR in the kidney regulates urine volume, osmolality, and lipid metabolism. It has protective effects against acute kidney injury, chronic kidney disease, diabetic nephropathy, and vascular diseases through anti-inflammatory, antifibrotic, antilipogenic, and antioxidant effects. It also plays regulatory roles in glucose metabolism.

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