Table 2 The role of demethylases and their regulated ncRNAs in various cancers.

From: The roles of N6-methyladenosine and its target regulatory noncoding RNAs in tumors: classification, mechanisms, and potential therapeutic implications

Eraser

Role in cancer

Type

Target ncRNAs

Mechanism

FTO

Oncogene

ESCC

LNC0002299

Stability

CC

LncHOXC13-AS100

Stability

ALKBH5

Oncogene

OS

LncPVT1104

Stability

GBM

LncNEAT1103

Stability

LSCC

LncKCNQ1OT1117

Stability

DLBCL

LncTRERNA1111

Scaffold

CRC

circ3823102

Stability

HCC

circCPSF6110

Stability

NSCLC

miR-21–5p112

Silencing potency

GC

LncNEAT1107

N/A

CRC

LncNEAT1109

N/A

LUAD

LncRMRP108

N/A

Tumor suppressor

ESCC

LNC00278106

Translation

Tumor suppressor

PAC

LncKCNK15-AS1105

N/A

  1. ESCC esophageal squamous cell carcinoma, CC cervical cancer, OS osteosarcoma, GBM glioblastoma multiforme, LSCC laryngeal squamous cell carcinoma, DLBCL diffuse large B-cell lymphoma, CRC colorectal cancer, HCC hepatocellular carcinoma, NSCLC non-small cell lung cancer, GC gastric cancer, LUAD lung adenocarcinoma, PAC pancreatic cancer.
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