Fig. 4: Bioinformatic analysis revealed an inflammatory response and lipid metabolism changes in Nlrp3−/− rats 3 days after ICH-IVH. | Experimental & Molecular Medicine

Fig. 4: Bioinformatic analysis revealed an inflammatory response and lipid metabolism changes in Nlrp3−/− rats 3 days after ICH-IVH.

From: NLRP3-dependent lipid droplet formation contributes to posthemorrhagic hydrocephalus by increasing the permeability of the blood–cerebrospinal fluid barrier in the choroid plexus

Fig. 4

A Heatmap of differentially expressed genes from transcriptome sequencing of Nlrp3−/− rats versus WT rats. B Heatmap of differentially expressed proteins from proteome sequencing. C GSEA of sequencing results showing a diminished inflammatory response and altered lipid metabolism in Nlrp3−/− rats. D Network images showing inflammatory, lipid-related, and potentially related genes after ICH-IVH with or without NLRP3 knockout. E Protein–protein interaction network of inflammatory and lipid-related proteins.

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