Fig. 6: NLRP3 mediates tight junction dysfunction by altering LD formation. | Experimental & Molecular Medicine

Fig. 6: NLRP3 mediates tight junction dysfunction by altering LD formation.

From: NLRP3-dependent lipid droplet formation contributes to posthemorrhagic hydrocephalus by increasing the permeability of the blood–cerebrospinal fluid barrier in the choroid plexus

Fig. 6

A T2-weighted and 3D reconstruction images showed lateral ventricles and volume analysis results (n = 3, unpaired t test). B Statistical analysis of the mNSS results (n = 6, unpaired t test). C Trajectory images and analysis results of the open-field tests with and without CAY10650 treatment after ICH-IVH (n = 6, unpaired t test). D Western blot detection of NLRP3 and PLIN3 in the choroid plexus and quantified abundance results (n = 3, 6 rats per sample, one-way ANOVA). E Western blot images and statistical results showing the expression of the tight-junction-related proteins ZO-1 and claudin-5 in the choroid plexus (n = 3, 6 rats per sample, one-way ANOVA). The results are expressed as the mean ± SD, **P < 0.01.

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