Fig. 4: Regulation of STING and the downstream signaling pathway.
From: Molecular mechanisms of mitochondrial DNA release and activation of the cGAS-STING pathway
Upon binding to cGAMP, STING undergoes a conformational change, and then, the dimers oligomerize. STING oligomerization recruits TBK1 and promotes autotransphosphorylation of TBK1 at the ERGIC. Activated TBK1 phosphorylates the CTT of STING to generate IRF3 docking sites and then phosphorylates the recruited IRF3.
