Fig. 5: Posttranslational modification in the cGAS-STING pathway.
From: Molecular mechanisms of mitochondrial DNA release and activation of the cGAS-STING pathway
Mitochondrial stress induces the release of mtDNA and subsequently activates the cGAS-STING pathway. This signaling pathway can be regulated by various posttranslational modifications and can also be suppressed by caspases during apoptosis.
