Fig. 5: Treatment with regorafenib resulted in amelioration of emphysema and attenuation of senescence in PPE-treated mice. | Experimental & Molecular Medicine

Fig. 5: Treatment with regorafenib resulted in amelioration of emphysema and attenuation of senescence in PPE-treated mice.

From: Defining regorafenib as a senomorphic drug: therapeutic potential in the age-related lung disease emphysema

Fig. 5

a Experimental scheme. b Representative H & E images of the lungs. Scale bars, 100 μm c Quantification of the mean chord length (Lm) in the three groups. d Lung function test. The parameters Cst (static compliance), A (total lung capacity) and K (shape of the deflation limb of the PV loop) are shown. e Representative images of SA-β-Gal-stained lungs. f Quantification of the data in e. g Representative images of p16INK4a- and p21WAF1-stained lungs. h, i Quantification of p16INK4a (h) and p21WAF1 (i) expression as shown in g. Scale bars in e, f, 100 μm and 20 μm (enlarged). The error bars indicate the means ± SEMs, N = 5 mice per group, *p < 0.05, **p < 0.01, ***p < 0.001, t-test.

Back to article page