Fig. 8: Structure of WT and mutant KCNQ4 proteins predicted using AlphaFold2.
From: Overlooked KCNQ4 variants augment the risk of hearing loss
a Structure of the WT KCNQ4 channel predicted using AlphaFold2. b Pore configuration of the WT KCNQ4 channel. The pore radius and electrostatic potential energy (Ф) were calculated using the HOLE and linearized Poisson–Boltzmann equations, respectively. Residues that are important for channel function are described. c–l Pore radius of KCNQ4 variants. The pore radius of each variant is colored in red and that of the WT is in gray.
