Fig. 7: Lpc-EV treatment increased neurogenesis and MAP-2-stained density of hippocampal dendritic processes in Tg-APP/PS1 mice. | Experimental & Molecular Medicine

Fig. 7: Lpc-EV treatment increased neurogenesis and MAP-2-stained density of hippocampal dendritic processes in Tg-APP/PS1 mice.

From: Lactobacillus-derived extracellular vesicles counteract Aβ42-induced abnormal transcriptional changes through the upregulation of MeCP2 and Sirt1 and improve Aβ pathology in Tg-APP/PS1 mice

Fig. 7

a–c Diagram of the regions examined for immunohistochemical analyses (a). Anti-MAP2 staining levels in the stratum radiatum of the indicated groups (b). Photomicrographs showing anti-MAP2-stained dendritic processes of pyramidal neurons in the stratum radiatum (c) in the CA1 region of WT-CON, Tg-CON and Tg-Lpc-EV mice. Higher magnification (low panels) of the boxed areas (c) of the indicated groups. The red box in the CA1 of (a) is the region for the images in (c) (upper panels). n = 9–12 animals. F(2,30) = 6.385, p = 0.0049. d, e The numbers of anti-doublecortin (DCX)-positive cells in the dentate gyrus (DG) of WT-CON, Tg-CON, and Tg-Lpc-EV mice (d). Photomicrographs showing anti-doublecortin (DCX)-stained cells in the dentate gyrus of the indicated groups (e). The red box in the DG of (a) is the region for the images in (e) (upper panels). Higher magnification (lower panels) of the boxed areas (e) of the indicated groups. n = 10–13 animals. F(2,31) = 5.136, p = 0.0118. Data are presented as the mean ± SEM. *, **, #, difference between the indicated groups. *, #, p < 0.05; **p < 0.01 (one‐way ANOVA followed by Newman‒Keuls post hoc test).

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