Fig. 7: Compromised translation of COVID-19 signature genes in mouse tissues. | Experimental & Molecular Medicine

Fig. 7: Compromised translation of COVID-19 signature genes in mouse tissues.

From: SARS-CoV-2 infection engenders heterogeneous ribonucleoprotein interactions to impede translation elongation in the lungs

Fig. 7

a UMAP visualization of the single-cell transcriptome from lung samples taken during the autopsies of COVID-19 and non-COVID-19 patients4. The datasets from the patients with acute symptoms and early deaths (5–16 days from symptom appearance to death) were selected and re-analyzed. Cell types (left) and origins (right) are indicated by different colors. b Single-cell expression of human homologs of the up- (left) and downregulated (right) genes of the mouse lung translatome 7 dpi. See also Supplementary Fig. 7a for results obtained 1, 2, and 5 dpi. c Collective expression of human homologs of the up- or downregulated genes of the mouse tissue translatomes 1, 2, 5, and 7 dpi (left) and of the human cell line translatome (right) in non-COVID-19 (blue) and COVID-19 (orange) donor group 8 dpi. d Discretized bar plots showing comparisons between RD FCs of mouse homologs of collective non-COVID-19 and COVID-19 signatures at individual time points postinfection. e Violin plots showing the RD FCs of mouse homologs of cell type-specific non-COVID-19 and COVID-19 signatures. RD FC obtained 2 dpi and 7 dpi are shown.

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