Fig. 5: CMP-conjugated dCas9-based base editors enhance base editing efficiencies without undesired indels in mouse targets.
From: Precise base editing without unintended indels in human cells and mouse primary myoblasts
a, b Comparisons of C-to-T conversions and indel efficiencies of AncBE4max, AncdBE4max, and dBP2b in eight mouse gene targets. c Fold change in the base conversion efficiency of dBP2b compared with AncdBE4max. d, e Efficiencies of A-to-G substitutions in CMP-conjugated or CMP-unconjugated ABE8e variants. f Fold change in base conversion efficiency of dAP1b8e compared with dABE8e. dAP1b8e promotes base editing efficiency at all targets in mouse Neuro2a. The data are shown as the mean ± S.E.M. of the independent experiments in (c, f). Each dot represents an individual target experiment. Control indicates the untreated group.
