Fig. 8: Mechanistic model for CYB5R3-induced lung cancer cell death. | Experimental & Molecular Medicine

Fig. 8: Mechanistic model for CYB5R3-induced lung cancer cell death.

From: CYB5R3 functions as a tumor suppressor by inducing ER stress-mediated apoptosis in lung cancer cells via the PERK-ATF4 and IRE1α-JNK pathways

Fig. 8

In lung cancer cells, CYB5R3 is downregulated, and CYB5R3 overexpression promotes cell death by inducing ER stress and ROS generation. CYB5R3 activates the PERK-ATF4-CHOP and IRE1α-JNK pathways through ADP-ribosylation mediated by PARP16. ROS generation induced by CYB5R3 activates caspase-9-dependent cell death.

Back to article page