Fig. 3: The OAT concentration in bronchoalveolar lavage fluid (BALF) is associated with lung function and the survival of patients with IPF. | Experimental & Molecular Medicine

Fig. 3: The OAT concentration in bronchoalveolar lavage fluid (BALF) is associated with lung function and the survival of patients with IPF.

From: Role of lung ornithine aminotransferase in idiopathic pulmonary fibrosis: regulation of mitochondrial ROS generation and TGF-β1 activity

Fig. 3

a OAT protein levels in BALF were quantified using enzyme-linked immunosorbent assays (ELISAs). The data are expressed as medians with 25% and 75% quartiles. *p < 0.05 versus the control group. b Correlations between BALF OAT levels and forced vital capacity (FVC; % pred.) and c between BALF OAT levels and diffusing capacity of the lung for carbon monoxide (% pred.) in patients with IPF. d Receiver operating characteristic curve analysis to determine the optimal OAT concentration that could be used as cutoff values for predicting survival in 59 patients with IPF. e. Comparison of OAT level survival curves using Kaplan–Meier plots. The survival rate was markedly lower in the group with an OAT level ≥75.659 ng/mL (red line) than in the group with an OAT level <75.659 ng/mL (blue line; hazard ratio, 29.53; 95% confidence interval, 7.29–119.55; p < 0.0001). f Comparison of FVC in terms of BALF OAT levels. The data are expressed as medians with the 25% and 75% quartiles. #p < 0.05 versus the OAT < 75.659 ng/mL group.

Back to article page