Fig. 3: Schematic of MITF downstream targets and their role in myeloid cells.
From: Emerging roles of MITF as a crucial regulator of immunity
Many of the MITF downstream effectors (e.g., HIF-1α, GPNMB, C/EBPα and IRF4) are associated with the differentiation and functions of immune cells, including macrophages, MDSCs, DCs and neutrophils.
