Fig. 9: The relationships between the positions of the ATF4-, mTOR-, and AGE-positive areas and calcification areas in the mouse meniscus. | Experimental & Molecular Medicine

Fig. 9: The relationships between the positions of the ATF4-, mTOR-, and AGE-positive areas and calcification areas in the mouse meniscus.

From: Advanced glycation end products promote meniscal calcification by activating the mTOR-ATF4 positive feedback loop

Fig. 9

a Diabetic model and control mice were given different intra-articular knee injections after ACLT surgery. The knee joints were collected at 8 weeks for sectioning. Immunofluorescence analysis and ALP staining of knee joint sections from the different groups. Red arrows, ALP-positive areas. Black arrows, ATF4-, p-mTOR- and AGE-positive areas. Scale bar: 50 μm. b Three-dimensional micro-CT images of the meniscal calcification area in the different groups. Red arrows, cavernous structures within the calcification area.

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