Fig. 2: CN shows a similar gene expression pattern to that of radial glial cells in the bulk RNA sequencing data. | Experimental & Molecular Medicine

Fig. 2: CN shows a similar gene expression pattern to that of radial glial cells in the bulk RNA sequencing data.

From: Central neurocytoma exhibits radial glial cell signatures with FGFR3 hypomethylation and overexpression

Fig. 2

a Upper schematic figure showing various stages of neural precursor cells in the normal brain and their progression. The arrow shows the expected paths of the cells during normal neural differentiation. Lower bar charts show the combined gene expression patterns of these different neural developmental cell marker genes in CN and normal brain samples. Significant overexpression of genes related to radial glial and intermediate progenitor cells was detected in CN (asterisks represent the following P values, *<0.05; **<0.01; ***<0.001; ****<0.0001). b Individual marker gene expression patterns showing significant overexpression of all marker genes representing radial glial cells and intermediate progenitor cells in CN compared to the normal brain (asterisks represent the following P values, *<0.05; **<0.01; ***<0.001; ****<0.0001). c IHC validation of radial glial and intermediate progenitor cell marker genes showing that only radial glial marker genes are upregulated in CN, confirming that radial glial cells are the cell type of origin (scale bar 100 µM).

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