Fig. 4: FGFR3 hypomethylation in CN. | Experimental & Molecular Medicine

Fig. 4: FGFR3 hypomethylation in CN.

From: Central neurocytoma exhibits radial glial cell signatures with FGFR3 hypomethylation and overexpression

Fig. 4

a t-SNE clustering based on methylation data showing that the CN samples from this study clustered exclusively with the public CNS data from the CN cluster, confirming accurate classification of the samples as CN. CN-SNUH represents the samples from the present study (n = 6), and CN-DFKZ represents the samples from comparison of public methylation data (n = 21). b The FGFR3 gene had the highest percentage among DMR/non-DMR ratios. c FGFR3 was hypomethylated compared to normal brain samples according to methylation expression data. d FGFR3-specific CpG probes (n = 3) showed significant hypomethylation compared to that in other CNS tumors and normal brain samples. The CN samples indicated by red circles contain 6 samples from the present study and 21 samples obtained from the public DFKZ CNS methylation database. e Correlation plot of methylation ratios with FPKM values showing a significant negative correlation for all three FGFR3-specific probes.

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