Fig. 5: Schematic representation of the potential mechanism of CN tumorigenesis. | Experimental & Molecular Medicine

Fig. 5: Schematic representation of the potential mechanism of CN tumorigenesis.

From: Central neurocytoma exhibits radial glial cell signatures with FGFR3 hypomethylation and overexpression

Fig. 5

The middle left and upper panels show the normal course of radial glial cell differentiation into mature neurons. The middle right and lower panels show the potential course of CN tumorigenesis, whereby FGFR3 hypomethylation-driven FGFR3-overexpressing radial glial-like cells progress through the ventricle as a result of PIK3-AKT activation and altered neuronal functions such as differentiation and migration.

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