Fig. 3: RNA modification-induced epitranscriptomic modification of regulatory RNAs.
From: Molecular insights into regulatory RNAs in the cellular machinery
Many RNA modifications, including m6A, m5C, 2′-O-Me, A-to-I, and ψ, have been identified in various RNAs. Multiple epitranscriptomic RNA modifications regulate and modulate cellular functions such as miRNA maturation, mRNA stability, gene expression, translation efficiency, degradation, and ESC differentiation. Additionally, these modifications are associated with various pathophysiological conditions, including gastric cancer, HCC, and leukemogenesis.
