Fig. 4: Cooperation between regulatory RNAs and RNA-binding proteins.
From: Molecular insights into regulatory RNAs in the cellular machinery
a U2 snRNA participates in the splicing process by recognizing the branch point, a process assisted by U2AF on the Py track near the 3’ splice site. MALAT1 and SR proteins form intron lariats for alternative splicing. b NEAT1 is a well-defined scaffolding lncRNA localized in paraspeckles in the nucleus that can sequester proteins such as NONO and SFPQ. NEAT1 also mediates chromatin remodeling by binding to ARID1B. c BRD4 recognizes acetylated K residues in a manner mediated by eRNAs and regulates HOTAIR expression levels. HOTAIR facilitates transcriptional regulation via LSD1 recruitment.
