Fig. 4: Current stem cell models used to study inherited peripheral neuropathies (IPNs).
From: Advances and challenges in modeling inherited peripheral neuropathies using iPSCs
The figure shows various stem cell models. The upper blue panel represents monocultures, while the lower panel illustrates more complex models, from 2D to 3D cocultures, grown in microfluidic devices or as neuromuscular assembloids or organoids containing multiple cell types. The right blue panel depicts the potential use of these models in combination with mice (known as humanized mouse models). Finally, the figure also highlights the ability of these models to contribute to the assessment of therapeutics and gene-editing approaches or the identification of potential biomarkers. Created with BioRender.com.
