Fig. 7: Schematic showing how activation of the osteoblastic HIF-1α pathway alleviates the symptoms of STZ-induced T1DM via RegIIIγ. | Experimental & Molecular Medicine

Fig. 7: Schematic showing how activation of the osteoblastic HIF-1α pathway alleviates the symptoms of STZ-induced T1DM via RegIIIγ.

From: Activation of the osteoblastic HIF-1α pathway partially alleviates the symptoms of STZ-induced type 1 diabetes mellitus via RegIIIγ

Fig. 7

a HIF-1α increases RegIIIγ gene expression by binding to the promoter region of RegIIIγ. b RegIIIγ secreted by osteoblasts enters the blood circulation. c Osteoblast-derived RegIIIγ enters the pancreas through the blood circulation. d Osteoblast-derived RegIIIγ decreases STZ-induced β cell injury. e SF-DFO activates the osteoblastic HIF-1α-RegIIIγ pathway to alleviate STZ-induced pancreatic β cell injury. This scheme was created with BioRender.com.

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