Fig. 4: The mature forms of IL-33 differentially regulate angiogenic genes. | Experimental & Molecular Medicine

Fig. 4: The mature forms of IL-33 differentially regulate angiogenic genes.

From: A neutrophil elastase-generated mature form of IL-33 is a potent regulator of endothelial cell activation and proliferative retinopathy

Fig. 4

Quiescent HRMVECs were treated with or without IL-3395–270, IL-3399–270, IL-33109–270, and IL-33112–270 (20 ng/mL), and total cellular RNA was extracted and subjected to mRNA sequencing. a Venn diagram showing the number of angiogenic genes regulated by IL-3395–270, IL-3399–270, IL-33109–270, and IL-33112–270 compared to the control. b Heatmap showing the expression profile of angiogenic genes regulated by IL-3395–270 in HRMVECs. c Heatmap showing the expression profile of angiogenic genes regulated by IL-3399–270 in HRMVECs. d Heatmap showing the expression profile of angiogenic genes regulated by IL-33109–270 in HRMVECs. e Heatmap showing the expression profile of angiogenic genes regulated by IL-33112–270 in HRMVECs. The differentially expressed genes in the heatmap that were regulated only by specific mature versions of IL-33 are highlighted in red.

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