Fig. 8: Influence of MD-1-induced NETs production on atherosclerotic unstable plaque formation in ApoE-/- mice. | Experimental & Molecular Medicine

Fig. 8: Influence of MD-1-induced NETs production on atherosclerotic unstable plaque formation in ApoE-/- mice.

From: Neutrophil extracellular traps mediate the crosstalk between plaque microenvironment and unstable carotid plaque formation

Fig. 8

a Representative images of carotid plaques from each group of mice stained with HE, oil red O, and Masson trichrome to evaluate the stability of carotid plaques (scale bar = 100 μm). b The levels of NETs in the plasma of mice in each group were measured by ELISA. c Quantification of MD-1 within the plaques of mice in each group by immunohistochemical staining and representative images of each group (scale bar = 100 μm). d Quantification of MD-1 in the plasma of mice in each group was performed by ELISA. e Immunofluorescence staining for CD31 (red) showing representative images of neovascularization conditions within the plaques of mice and the calculated MVD in each group (scale bar = 50 μm). f Expression levels of VCAM1, ICAM1, MMP14, VEGFA, and IL6 in the plasma of mice in each group were measured by ELISA.

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