Fig. 2: Evidence of increased senescence in patients with chronic liver disease.
From: Accelerated aging of skeletal muscle and the immune system in patients with chronic liver disease
a SenMayo gene set enrichment analysis of the skeletal muscle tissue of CLD patients (n = 24) compared to that of healthy controls (n = 18). The data are presented as an enrichment plot (left) and a heatmap of the top 10 most enriched SenMayo genes in the CLD group (right). b Top 10 most enriched SenMayo genes in the skeletal muscle tissue of CLD patients c, d Serum concentrations of TNF-alpha and TNF-beta in CLD patients (n = 23) and healthy controls (n = 18). e Serum concentrations of KITLG (pseudonyms: stem cell factor (SCF) and mast cell growth factor (MGF)) in patients with CLD and healthy controls. f–h Enrichment plots following gene set enrichment analysis of the SenMayo gene set in the skeletal muscle tissue of the ArLD (n = 13), immune-mediated (n = 7), and NAFLD (n = 4) subgroups in comparison to healthy controls. The data are presented as the mean ± SEM. ArLD alcohol-related liver disease, NAFLD nonalcoholic fatty liver disease.
