Fig. 3: Landscapes of somatically acquired mutations in cancer genomes.
From: Clinical application of whole-genome sequencing of solid tumors for precision oncology
a Comparison of tumor mutational burden (TMB) between Pan-Cancer Analysis of Whole-Genomes (PCAWG) and this study. Two studies showed similar TMBs in two cancer types. Every dot represents a sample, and the red horizontal lines are the median TMBs in the respective cancer type. b Landscape of somatically acquired mutations in 95 solid tumors in this study. Top to bottom: tumor mutational burden (TMB), cancer type, microsatellite instability (MSI) score, homologous recombination deficiency (HRD) score, tumor cell fraction estimated from WGS, genome ploidy, sample type (fresh-frozen or FFPE), sample acquisition method (biopsy or surgery), point mutations in frequently mutated cancer genes, mutational signatures (SBS, ID, and SV), and copy number alterations. c Cancer genes frequently altered by SVs (arcs inside the circle) and copy number changes (dots outside the circle). d A representative Circos plot summarizing all the somatic mutations (from outer to inner circles; chromosomes, point mutations with variant allele fraction (VAF), point mutations with intermutational distance, genome-wide loss-of-heterozygosity (LOH) pattern, genome-wide copy number changes, and SVs).
