Fig. 1: Genomic profile of tRCC.

a A clinical and genomic overview of 15 pathologically confirmed tRCC and four ccRCC tumors. b Number of somatic SNVs and the genomic portion of structural changes between tRCC and ccRCC samples. c Differences in the correlation between the number of somatic SNVs and patient age. d Schematic diagram representing TFE3 fusion events identified by RNA-seq. For each gene, the upper diagrams denote the gene structure with alternating exons and introns. The lower diagrams show the protein structure. tRCC translocation renal cell carcinoma, ccRCC clear cell renal cell carcinoma, SNVs single nucleotide variations, WES whole exome sequencing, FISH fluorescence in situ hybridization, TCGA The Cancer Genome Atlas, LOH loss of heterozygosity.