Fig. 5: Interactions between Gi and α2A-AR or β1-AR.
From: Distinct binding conformations of epinephrine with α- and β-adrenergic receptors
a–c Details of the interactions between Gi and α2A-AR. d K345 from Gi interacts with both α2A-AR and β1-AR. e Different residues in ICL2 (I154 from α2A-AR or F147 from β1-AR) contribute to the hydrophobic interactions with L194 from the β2-β3 loop and F336 from the C-terminal α5-helix of Gαi.
