Fig. 7: Inflammation induces Cbx4-mediated SUMOylation of BRD4. | Experimental & Molecular Medicine

Fig. 7: Inflammation induces Cbx4-mediated SUMOylation of BRD4.

From: Cbx4 SUMOylates BRD4 to regulate the expression of inflammatory cytokines in post-traumatic osteoarthritis

Fig. 7

a, b Relative protein expression levels in synovial fibroblasts determined by western blotting. c, d The levels of SUMO1 and SUMO2/3 in BRD4 immunoprecipitates from rat synovial cells were determined via co-IP, which revealed the presence of SUMO-modified BRD4 products. e, f Relative mRNA expression levels of IL-1β, TNF-α and IL-6 determined by qPCR. In a, b, e, and f, n = 3, one-way ANOVA. *P < 0.05; **P < 0.01; ***P < 0.005.

Back to article page