Table 1 SMYD2 functions in cancer.

From: SMYD family in cancer: epigenetic regulation and molecular mechanisms of cancer proliferation, metastasis, and drug resistance

Functions

Description

References

Proliferation

SMYD2-mediated MNAT1 upregulation was suggested to activate the PI3K/AKT pathway in pancreatic cancer

27

SMYD2 knockdown suppresses proliferation via the positive regulation of c-Myc expression in prostate cancer

28

SMYD2 regulates H3K36me2 levels on MEX3A in colorectal cancer

28

SMYD2 regulates the ERBB2/FUT4 signaling pathway in colorectal cancer

29

SMYD2 upregulates the MCAM gene and is involved in regulating cancer stem cell characteristics in breast cancer

33

SMYD2 knockdown increases apoptotic cell death and reduces anchorage-independent transformation in leukemia

35

SMYD2 overexpression regulates miR-125b expression in renal cancer

38

SMYD2 increases RNA-binding activity via the monomethylation of K422 on HNRNPK in colorectal cancer

39

SMYD2 binding to RIPK1 inhibits RIPK1 phosphorylation in colorectal cancer

40

SMYD2 positively regulates DNMT1 in colorectal cancer

42

SMYD2 regulates the expression of glucose metabolism-related genes by changing the methylation of p53 at K370 in cervical cancer

43

Metastasis

Monomethylation of BCAR3 lysine K334 by SMYD2 regulates the actin cytoskeleton

44

SMYD2 directly controls SMAD3 expression in lung cancer

45

SMYD2 regulates RPS7 expression in lung cancer

46

Drug resistance

SMYD2 regulates AR protein stability through nonhistone methylation in prostate cancer

57.

SMYD2 inhibition increases cell apoptosis via regulation of the p53 pathway (p21, Bax, and GADD45) in lung cancer

58

Oxaliplatin sensitivity is controlled via regulation of MDR1/P-glycoprotein by SMYD2 in colorectal cancer

59

SMYD2 inhibitors and miRNAs

LLY-507 inhibits lung cancer tumor growth

47

LLY-507 increases the levels of Sub-G1 and cleaved PARP

49

OC reduces SMYD2 expression

50

Baicalein inhibits SMYD2 expression

51

The long non-coding RNA DLEU1 binds to SMYD2 and translocates to the APOC1 gene promoter

47

Negative correlation between miR-200b expression and SMYD2 expression

52

  1. MNAT1 MNAT1 component of CDK-activating kinase, MEX3A Mex-3 RNA-binding family member A, ERBB2 Erb-B2 receptor tyrosine kinase 2, FUT4 fucosyltransferase 4, MCAM melanoma cell adhesion molecule, RIPK1 receptor-interacting serine/threonine kinase 1, DNMT1 DNA methyltransferase 1, BCAR3 BCAR3 adapter protein, NSP family member, SMAD3 SMAD family member 3, RPS7 ribosomal protein S7, OC S-(-)-oleocanthal, DLEU1 deleted in lymphocytic leukemia 1, APOC1 apolipoprotein C1.
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