Fig. 3: Cellular trajectories of neurological disorder risk genes in nonneuronal lineages.

UMAP visualization of estimated developmental lineages in the oligodendrocyte group (C0, C8, C9, and C38), colored by pseudotime (a) and developmental stage (b). c Distribution of cells by major cell type and clustering across pseudotime and temporal patterns of PDGFRA and OPALIN. d Expression profiles of neurological disorder risk genes across pseudotime for different lineages. e Functional annotations for early- and late-lineage cells with significantly enriched biological processes with multiple comparisons by FDR. f UMAP visualization of the estimated developmental lineage in the astrocyte group (C2 and C29). g Distribution of cells by developmental stage across pseudotime. h Expression profiles of neurological disorder risk genes across pseudotime for each lineage. i Distinct expression patterns of known astrocyte marker genes in each lineage. j Functional annotations for each lineage with significantly enriched biological processes with multiple comparisons by FDR.