Fig. 6: Schematic illustration of the generation of the heteroplasmic MT-ND5 gene knockout and its effects on mitochondria and the resulting phenotype.
From: Comprehensive phenotypic assessment of nonsense mutations in mitochondrial ND5 in mice
Heteroplasmic knockout of the MT-ND5 gene induced by DdCBE results in the disruption of Complex I, impaired ATP synthesis, and destruction of the CRISTA structure. These defects lead to brain- and fat-related phenotypes.
