Fig. 1: Reduced thermal sensitivity in systemically glucose- or GLP-1 treated- and locally GLP-1 treated-mice and the analgesic effect of GLP-1 on CAP-induced nociceptive behaviors in mice. | Experimental & Molecular Medicine

Fig. 1: Reduced thermal sensitivity in systemically glucose- or GLP-1 treated- and locally GLP-1 treated-mice and the analgesic effect of GLP-1 on CAP-induced nociceptive behaviors in mice.

From: GLP-1 and its derived peptides mediate pain relief through direct TRPV1 inhibition without affecting thermoregulation

Fig. 1

a Effects of intraperitoneal (i.p.) administration of 2 g/kg glucose on heat sensitivity according to the hot plate test (mean ± S.E.M., n = 5). Two-way ANOVA followed by the Bonferroni multiple comparison test (*p < 0.05, compared with the saline group). Effects of intraperitoneal (b) and oral (c) administration of 10 μg/kg GLP-1(7–36) (GLP-1) on heat sensitivity via the hot plate test (mean ± S.E.M., n = 5 ~ 7). Two-way ANOVA followed by the Bonferroni multiple comparison test (*p < 0.05, ***p < 0.001, compared with the saline group). d Effects of intraplantar administration (i.pl.) of 10 μg of GLP-1(7–36) on heat sensitivity via the Hargreaves test (mean ± S.E.M., n = 5). Two-way ANOVA followed by the Bonferroni multiple comparison test (*p < 0.05, ***p < 0.001, compared with the saline group). e Effects of intraplantar administration of 10 μg of GLP-1(7-36) on the CAP (1.6 μg)-induced spontaneous licking time (mean ± S.E.M., n = 5). Two-tailed unpaired t test (****p < 0.0001, compared with the saline group). Schematic illustration of the analgesic effect through systemic GLP-1 secretion (f) and local GLP-1 induction (g). ANOVA analysis of variance, CAP capsaicin, GLP-1 glucagon-like peptide-1, S.E.M. standard error of the mean.

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