Fig. 1: Running retards AFP-induced disc degeneration in rats. | Experimental & Molecular Medicine

Fig. 1: Running retards AFP-induced disc degeneration in rats.

From: The muscle–intervertebral disc interaction mediated by L-BAIBA modulates extracellular matrix homeostasis and PANoptosis in nucleus pulposus cells

Fig. 1

a Treadmill for SD rats. b Body weight changes in SD rats in three groups (CTR, AFP and AFP + R). c MRI scans of the caudal spine in SD rats. d Pfirrmann scores based on MRI scans of the caudal spine in SD rats. e Histological scoring of IDD in SD rats based on hematoxylin‒eosin (HE) staining. f Slices of the rat caudal vertebra were subjected to HE, safranin O and fast green (SF) staining. Scale bar: 50 μm. g Respective immunohistochemical (IHC) staining results for COL2A, ACAN, ADAMTS5 and MMP3 in the three groups (CTR, AFP and AFP + R). Scale bar: 20 μm. h Semiquantitative and statistical analysis of IHC results for COL2A, ACAN, ADAMTS5 and MMP3. The data are shown as the means ± SDs; *p < 0.05.

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