Fig. 5: Trogocytosis of antibody-coated tumor cells by macrophages, monocytes, and neutrophils.
From: Trogocytosis-mediated immune evasion in the tumor microenvironment
Neutrophils, macrophages, and monocytes undergo trogocytosis when in contact with antibody-coated tumor cells. Interactions between CD11b/CD18 integrins and adhesion molecules on the tumor cell surface establish a cytotoxic synapse. At this synapse, the Fc gamma receptor (FcγR) binds to trastuzumab bound to HER2, initiating trogocytosis and transferring membrane molecules from breast cancer cells to innate immune cells. A similar process occurs with rituximab-coated leukemia cells. Notably, significant tumor cell membrane loss leads to trogocytosis-mediated apoptosis, known as trogoptosis.
