Fig. 6: Partial restoration of the inflammaging signature in NSG mice transplanted with Omicron PsV-infected HSPCs treated with NGO. | Experimental & Molecular Medicine

Fig. 6: Partial restoration of the inflammaging signature in NSG mice transplanted with Omicron PsV-infected HSPCs treated with NGO.

From: SARS-CoV-2 pseudovirus dysregulates hematopoiesis and induces inflammaging of hematopoietic stem and progenitor cells

Fig. 6

a Schematic of the in vivo experiment depicting NSG mice transplanted with Omicron PsV-infected HSPCs, with groups either receiving NGO treatment or left untreated (n = 5–7 per group). b Engraftment levels (hCD45+) in mouse PB were quantified using flow cytometry to compare the treated and untreated groups. c, d Percentages of hCD34+ cells (c) and LT-HSCs (d) in the BM were assessed by flow cytometry, and both treatment conditions were compared. e Transcription levels of inflammaging markers in the BM were quantified via qRT‒PCR to evaluate the effects of NGO treatment versus no treatment. Relative mRNA levels were normalized to those of hGAPDH. *P < 0.05, **P < 0.01, ***P < 0.001. The results are shown as the mean ± s.e.m.

Back to article page