Fig. 1: Pim1−/− male mice exhibit increased bone mass in the femur.
From: Pim1 promotes the maintenance of bone homeostasis by regulating osteoclast function
Eight-week-old WT and Pim1−/− male mice were used. a Representative μCT images of the femurs. Scale bars, 500 μm. b Average values of the indicated μCT-determined bone indices. c Histomorphometry of the femurs after TRAP staining. Left: representative TRAP-stained femur images. Scale bars, 200 µm. Right: average histomorphometry-determined values of the indicated osteoclast and osteoblast variables. No.OCs, number of osteoclasts/bone perimeter; No.Obs, number of osteoblasts/bone perimeter. d Serum levels of PINP and CTX-1. In a–c, n = 7–8 per group. In d, n = 3 per group. The data are shown as mean ± s.d. Statistical analysis was conducted with two-tailed unpaired Student’s t-test. *P < 0.05, ***P < 0.001.
