Fig. 6: A summary of enrichment of genes whose expression was reversed by LpEV in Drd2-KO mice. | Experimental & Molecular Medicine

Fig. 6: A summary of enrichment of genes whose expression was reversed by LpEV in Drd2-KO mice.

From: Lactobacillus paracasei-derived extracellular vesicles reverse molecular and behavioral deficits in mouse models of autism spectrum disorder

Fig. 6

a, b, Summary of selecting genes whose expression was reversed by LpEV in Drd2-KO mice, and following GO enrichment of selected genes (a). Genes in quadrants B and C in the RRHO map were selected for further analyses. Venn diagrams summarizing the number of genes identified in the dStr, NAc and dHP, and those overlapped between regions (b). c–h, Functional clusters of genes in a quadrant B in the dStr (c), NAc (e), and dHP (g) and a quadrant C in the dStr (d), NAc (f), and dHP (h). Key features in each cluster, the number of genes included and those (%) listed in the SAFRI database are summarized. i, j, The interaction networks of genes within the selected group. Genes overlapped among the dStr, NAc and dHP genes: genes (37 genes) commonly upregulated in Drd2-KO mice, with their altered expression reversed by LpEV (i), and those (21 genes) commonly downregulated in Drd2-KO mice, with their altered expression reversed by LpEV (j). Genes overlapped with SAFRI genes are marked with color shading, and those reidentified by a complementary approach (summarized in Fig. 7) are marked with green boxes.

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