Fig. 4: p53 directly participates in TK2 transcription.
From: Changes in mitochondrial thymidine metabolism and mtDNA copy number during induced pluripotency
a, Expression patterns of SIRT1, p53 acetylation (Lys 382), p21, TK2 and NANOG during somatic cell reprogramming. b, ChIP-qPCR analysis illustrating the binding activity of p53 to the TK2 promoter in fibroblasts and PSCs. c RT-qPCR analysis of p21 and TK2 expression in PSCs after 24 h of treatment with sirtinol (SIRT1 inhibitor). Results are presented as means ± s.d. (n = 3). *P < 0.05. Significant differences were analyzed using Student’s t-test or one-way ANOVA and Tukey’s multiple-comparison test. Statistical analyses were conducted using GRAPHPAD 8.0.1. ESC embryonic stem cell, PSC pluripotent stem cell.
