Fig. 4: Decreased number of BM ECs with hyperactivation of TGF-β signaling pathway in AA mice.
From: TGF-β inhibition restores hematopoiesis and immune balance via bone marrow EPCs in aplastic anemia
a, The establishment of classical AA mice with preirradiation and lymph node (LN) injection and schematic diagram of the different groups and treatments of the mice. b–d, The percentages of ECs (b) and the expression levels of TGFβ-RI (MFI) (c) and p-Smad2/3 (MFI) (d) in murine BM ECs. e, Representative images of BM vessels stained with an anti-endomucin antibody (scale bars, 10 μm) and BM sections stained with hematoxylin‒eosin (scale bars, 10 μm) in murine femurs. The green arrows represent normal vessels, the red arrows represent dilated vessels and the blue arrows represent discontinuous vessels in the murine femur. f, The percentages of normal and dilated as well as discontinuous BM vessels among the total vessels in the different murine groups. The data are presented as the mean ± s.e.m. (*P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001).
