Fig. 1: Diverse physiological roles of GPCR-targeting peptides around the human body. | Experimental & Molecular Medicine

Fig. 1: Diverse physiological roles of GPCR-targeting peptides around the human body.

From: Structural insights into GPCR signaling activated by peptide ligands: from molecular mechanism to therapeutic application

Fig. 1

Representative GPCR-targeting peptides and their associated physiological roles are summarized across various regions of the human body. The structure of each peptide represents its conformation when bound to its respective GPCR (PDB: (brain) 7W53, 7L1U, 8JBG, 8GY7, 8F7Q, 7F9Y, 7XJJ and 7VGX; (heart) 6JOD, 8XZG and 6PD1; (spinal cord) 8H0P; (kidney) 7DW9, 7TYO and 8FLU; (gut) 7EZH and 8IBV; (liver) 6LML; (uterus) 8I2G and 7RYC; (immune) 8HK5, 7SK3 and 7YKD, from left to right). Peptides are shown as cartoons or stick representations.

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