Fig. 3: Spatiotemporal FGFR1 activation identifies a distinct activation of downstream components over time in the dentate gyrus.
From: Dysregulation of FGFR1 signaling in the hippocampus facilitates depressive disorder
a A schematic representation of optoFGFR1 viral injection, activation tissue preparation, quant-sequencing and data analysis. b–d The scatter plots of 0.5 (b), 2 (c) and 12 h (d) FGFR1-activated genes versus 0 h control. e A Venn diagram of 0.5, 2 and 12 h of optoFGFR1 activation DEGs. f–h David analysis of fold enrichment in GO terms of biological process (BP), in 0.5 (f), 2 (g) and 12 h (h) FGFR1 activation. i A dot plot showing Notch signaling components, FGFR1 signaling cofactors and growth factors.
