Fig. 3: circCNOT6L promotes malignant progression of PCa cells at in vivo levels. | Experimental & Molecular Medicine

Fig. 3: circCNOT6L promotes malignant progression of PCa cells at in vivo levels.

From: CircCNOT6L modulates alternative splicing of SLC7A11 via splicing factor SRSF2 to confer ferroptosis resistance and promote metastasis in prostate cancer

Fig. 3

a Illustration of a subcutaneous tumor and lung metastasis model in nude mice. Nude mice were injected with PC3 cells of sh-NC and sh-circCNOT6L subcutaneously and through the tail vein, respectively. b–e Tumor samples derived from subcutaneous xenograft mice underwent IHC analysis (b) and tumor weight (c) and growth (d) were assessed (e). f–h The animal live imaging system was used to characterize the growth of lung tumors in nude mice (f) and to assess the number of metastatic foci of the tumor (g) in relation to the survival curve of the nude mice (h). i, j H&E staining reveals the size of the tumors in various samples (i), while IHC staining demonstrates the correlation between the expression of circCNOT6L and EMT-related proteins. (j) *P < 0.05, **P < 0.01, ***P < 0.001.

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