Fig. 2: A novel murine model with liver cirrhosis and ascites revealing the crucial role of portal hypertension ascites formation. | Experimental & Molecular Medicine

Fig. 2: A novel murine model with liver cirrhosis and ascites revealing the crucial role of portal hypertension ascites formation.

From: Portal hypertension contributes to ascites formation via the Piezo1−nuclear factor kappa-B−aquaporin1 pathway in liver cirrhosis

Fig. 2

a The experimental protocol for murine model with liver cirrhosis and ascites, murine model with liver cirrhosis and ascites was established through the administration of TAA/CCl4 followed by PPVL. b Portal pressure in the mice treated with TAA/CCl4 or TTA/CCl4 + PPVL. c Representative macroscopic views of abdominal cavity showing the accumulation of peritoneal fluid in TTA/CCl4 + PPVL-treated mice. d The assessment of ascites amount in cirrhotic mice. Left: the amount of ascites. Right: the amount of ascites in body weight. e Representative images of hepatic HE staining and Sirius red staining from cirrhotic liver. Right: the percentage of fibrotic area was quantified by Sirius red staining, f Serum ALB concentration in cirrhotic mice. g Serum ALT and AST levels in cirrhotic mice. *P < 0.05, **P < 0.01 and ***P < 0.001. ns, not significant.

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