Fig. 3: The critical role of endothelial Piezo1 in the development of portal hypertensive ascites using Piezo1△EC mice and Piezo1fl/fl mice. | Experimental & Molecular Medicine

Fig. 3: The critical role of endothelial Piezo1 in the development of portal hypertensive ascites using Piezo1△EC mice and Piezo1fl/fl mice.

From: Portal hypertension contributes to ascites formation via the Piezo1−nuclear factor kappa-B−aquaporin1 pathway in liver cirrhosis

Fig. 3

a The experimental protocol for cirrhotic mice with ascites using Piezo1△EC mice and Piezo1fl/fl mice. b Representative images of hepatic HE staining and Sirius red staining. c Evaluation of ascites in mice. Left: the amount of ascites. Right: the amount of ascites in body weight. d The percentage of fibrotic area was quantified by Sirius red staining. e Serum ALB concentration in mice. f Serum ALT and AST levels in mice. g Portal pressure in cirrhotic mice. *P < 0.05, **P < 0.01 and ***P < 0.001. ns, not significant.

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