Fig. 4: Portal hypertension induced AQP1 expression in peritoneal endothelium through Piezo1. | Experimental & Molecular Medicine

Fig. 4: Portal hypertension induced AQP1 expression in peritoneal endothelium through Piezo1.

From: Portal hypertension contributes to ascites formation via the Piezo1−nuclear factor kappa-B−aquaporin1 pathway in liver cirrhosis

Fig. 4

a A Venn diagram of differentially expressed mRNA in HUVEC exposed to laminar shear flow. The expression profile database of HUVECs exposed to laminar shear stress was extracted from four GEO datasets. Top: the Venn diagram for downregulated genes. Bottom: the Venn diagram for upregulated genes. b A heat map generated by robust rank aggregation method representing the expression of significantly changed genes from four databases. The results show 9 downregulated genes and 20 upregulated genes, with upregulation of AQP1 in HUVECs exposed to laminar shear stress. c A volcano plot illustrating gene distributions based on expression levels, the results show that AQP1 expression increased in HUVECs exposed to laminar shear stress. d Single-cell sequencing showing high hydrostatic pressure induced AQP1 expression in the vascular endothelium of the lungs. Left: a cluster analysis divided endothelial cells into six subgroups. Right: increased AQP1 expression in endothelial cells subsets in a murine model of pulmonary hypertension. PAH Pulmonary Hypertension, Umapccal Uniform Manifold Approximation and Projection Clustering Calibration, EC Endothelial Cell.

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