Fig. 2: Upregulated HOIL-1 expression associated with tumor progression in HCC. | Experimental & Molecular Medicine

Fig. 2: Upregulated HOIL-1 expression associated with tumor progression in HCC.

From: The LUBAC subunit HOIL-1 promotes the progression of HBV-associated hepatocellular carcinoma independently of linear ubiquitination

Fig. 2

a The expression of HOIL-1 in different stages of HCC development (including normal, chronic hepatitis, cirrhosis, dysplasia and HCC) in the GSE89377 cohort. b The expression of HOIL-1 in different stages of HCC development (including normal, fibrosis and HCC) in the GSE64041 cohort. c, The expression of HOIL-1 in fibrosis and HCC tissues relative to the normal tissues in the GSE45114 cohort. d–g The mRNA expression of HOIL-1 in tumor and nontumor tissues in TCGA LIHC (d), Oncomine (e), GSE14520 (f) and our (g) cohorts. h, i The expression of HOIL-1 in tumor and nontumor tissues was detected by western blot (h) and IHC (i) assays. j The expression of HOIP and SHARPIN in tumor and nontumor tissues was detected by western blot and the relative quantification. k The Kaplan–Meier analysis for OS and disease-free survival of patients with HCC with low and high expression of HOIL-1 in the TCGA LIHC cohort. l, m The Kaplan–Meier analysis for OS and disease-free survival of patients with HCC with low and high expression of HOIL-1 in GSE14520 (l, including all patients) and our cohort (m). The Kruskal–Wallis H test was used in a and b, the Mann–Whitney U test in e–j and the log-rank Mantel–Cox test in k and l. Data are shown as mean ± s.d., *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001. NS not significant, H&E hematoxylin and eosin staining, NT nontumor, T tumor.

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