Fig. 3: Targeting HOIL-1 expression inhibits the growth of HCC by regulating oncogenic pathways. | Experimental & Molecular Medicine

Fig. 3: Targeting HOIL-1 expression inhibits the growth of HCC by regulating oncogenic pathways.

From: The LUBAC subunit HOIL-1 promotes the progression of HBV-associated hepatocellular carcinoma independently of linear ubiquitination

Fig. 3

a The proliferation of Huh7 and HCCLM3 cells with the indicated treatment. b The EdU incorporation assays of Huh7 and HCCLM3 cells with the indicated treatment. c, d The representative image of the mouse bearing Huh7 (c)/HCCLM3 (d) cells and the quantification of tumor growth, n = 6. e The representative liver image of the DEN/CCl4-induced mouse HCC model, the quantification of maximum tumor diameter and the liver/body weight ratio (n = 9). f The representative image of hematoxylin and eosin (H&E) staining and the quantification of the tumor area. g The KEGG analysis of the differentially expressed genes in Huh7 and HCCLM3, treated as indicated. h The GSEA of Huh7 and HCCLM3, treated as indicated. The Mann–Whitney U test was used in a–f. Data are shown as mean ± s.d., *P < 0.05, **P < 0.01, ***P < 0.001. LV, lentiviral; sh, small hairpin.

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