Fig. 4: HOIL-1 expression is upregulated and associated with poor prognosis in HBV-HCC. | Experimental & Molecular Medicine

Fig. 4: HOIL-1 expression is upregulated and associated with poor prognosis in HBV-HCC.

From: The LUBAC subunit HOIL-1 promotes the progression of HBV-associated hepatocellular carcinoma independently of linear ubiquitination

Fig. 4

a–c The expression of HOIL-1 in the GSE14520 (a), GSE62232 (b) and GSE136247 (c) cohorts. d The expression of HOIL-1 in tumor and nontumor tissues in HBV-transgenic (HBV-Tg) HCC mouse models in the GSE103205 (left) cohort and hepatitis B surface antigen-transgenic (HBs-Tg) HCC mouse models in the GSE130668 (right) cohort. e The IHC detection of the HOIL-1 expression in HBV- and non-HBV-HCC tissues and the quantification of the IHC score. f The expression of HOIL-1 of HBV mouse model by hydrodynamic injection with the pAAV-HBV1.2 plasmid. g, h The expression of HOIL-1 in large (diameter >5 cm) and small (diameter ≤5 cm) tumor tissues (g) and in tumor tissues from patients with HCC with high (>300 ng/ml) and low (≤300 ng/ml) AFP levels (h) in the GSE14520 cohort and our cohort. i, j The Kaplan–Meier analysis for the OS and DFS of two groups of HBV-infected HCC patients defined by low and high expression of HOIL-1 in GSE14520 (i, only including 211 HBV-infected patients) and our cohort (j, only including 127 HBV-infected patients). The Kruskal–Wallis H test was used in a–d, the Mann–Whitney U test in e–g and the log-rank Mantel–Cox test in h. Data are shown as mean ± s.d., *P < 0.05, **P < 0.01, ***P < 0.001. DFS disease-free survival, IV intravenous.

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