Table 2 Histological characteristics
From: Selective insulin resistance with differential expressions of IRS-1 and IRS-2 in human NAFLD livers
Histological feature | Score | Control (n = 9) | SS (n = 19) | NASH (n = 23) |
|---|---|---|---|---|
| Â | Â | Number of biopsies (%) | ||
Steatosis | 0 = None (<5%) | 9 (100%) | 0 (0.0%) | 0 (0.0%) |
|  | 1 = Mild (5–33%) | 0 (0.0%) | 11 (57.9%) | 14 (60.9%) |
|  | 2 = Moderate (>33–66%) | 0 (0.0%) | 6 (31.6%) | 9 (39.1%) |
|  | 3 = Severe (>66%) | 0 (0.0%) | 2 (10.5%) | 0 (0.0%) |
Lobular inflammation | 0 = No foci | 9 (100%) | 1 (5.3%) | 0 (0.0%) |
|  | 1 = <2 foci | 0 (0.0%) | 15 (78.9%) | 11 (47.8%) |
|  | 2 = 2–4 foci | 0 (0.0%) | 3 (15.8%) | 11 (47.8%) |
|  | 3 = >4 foci | 0 (0.0%) | 0 (0.0%) | 1 (4.0%) |
Ballooning | 0 = None | 9 (100%) | 15 (78.9%) | 1 (4.3%) |
|  | 1 = Few balloon cells | 0 (0.0%) | 4 (21.1%) | 17 (73.9%) |
|  | 2 = Prominent ballooning | 0 (0.0%) | 0 (0.0%) | 5 (21.7%) |
Fibrosis | 0 = No | 9 (100%) | 5 (26.3%) | 0 (0.0%) |
|  | 1 = Mild, perisinusoidal | 0 (0.0%) | 11 (57.9%) | 2 (8.7%) |
|  | 2 = Perisinusoidal and portal/periportal | 0 (0.0%) | 3 (15.8%) | 6 (26.1%) |
|  | 3 = Bridging fibrosis | 0 (0.0%) | 0 (0.0%) | 10 (43.5%) |
|  | 4 = Cirrhosis | 0 (0.0%) | 0 (0.0%) | 5 (21.7%) |
